Patents & Publications



  1. L Sierad, R Pascal, A Simionescu, D Simionescu (2014). “Self-Adjusting Tissue Holder” UPSTO, #10,022,225

  2. L Sierad, SG Rankin, D Simionescu (2014). “Male fitting with actuating retaining feature” USPTO, #8,840,150

  3. L Sierad, L SHaw, G Fercana, D Simionescu (2014). “Decellularization Method and System and Decellularized Tissue Formed Thereby” USPTO, #10,293,082



  1. deBorde C, Simionescu D, Liao J, Sierad L, Wright C, Simionescu A (2016). “Stabilized collagen and elastin-based scaffolds for mitral valve tissue engineering”Tissue Eng Part A,22(21-22):1241-51. PMCID: PMC5107718

  2. Kennamer A, Sierad L, Pascal R, Rierson N, Albers C, Harpa M, Cotoi O, Harceaga L, Olah P, PredaT, Simionescu A, Simionescu D (2016). “Bioreactor conditioning of valve scaffolds seeded internally with adult stem cells”Tissue Eng Regen Med, 13(5):507-515. DOI:10.1007/s13770-016-9114-1

  3. Harpa M, Movileanu I, Sierad L, Cotoi O, Suciu H, Sircuta C, Preda T, Nistor D, Branzaniuc K,Deac R, Dandel M, Gurzu S, Harceaga L, Olah P, Simionescu A, Simionescu D (2016)“Pulmonary heart valve replacement using stabilized acellular xenogeneic scaffolds; effects of seeding with autologous stem cells”Rom Rev Lab Med, 23(4):415-430. DOI:10.1515/rrlm-2015-0046

  4. Harpa M, Movileanu I, Sierad L, Cotoi O, Suciu H, Preda T, Nistor D, Sircuta C, Branzaniuc K,Deac R, Gurzu S, Harceaga L, Olah P, Simionescu D, Dandel M, Simionescu A (2016). “In vivo testing of xenogeneic acellular aortic valves seeded with stem cells”Rom Rev Lab Med,24(3):343-346. DOI:10.1515/rrlm-2016-0031

  5. Sierad LN, Shaw EL, Bina A, Brazile B, Rierson N, Patnaik SS, Kennamer A, Odum R, Cotoi O,Terezia P, Branzaniuc K, Smallwood H, Deac R, Egyed I, Pavai Z,Szanto A, Harceaga L, SuciuH, Raicea V, Olah P, Simionescu A, Liao J, Movileanu I, Harpa M, Simionescu DT (2015).“Functional heart valve scaffolds obtained by complete decellularization of porcine aortic roots in a novel differential pressure gradient perfusion system”Tissue Eng Part C Methods,21(12):1284-96. PMCID: PMC4663650

  6. Roudsari L, Albers C, Doucet T, Floyd S, Hoffman C, Leaphart K, Patrick E, Roach B, MahoneyM, Sierad LN, Nagatomi J, Simionescu DT (2014) “Gelatin-Coated Resorbable Polymer Mesh as a Novel Scaffold for Aortic Heart Valve Tissue Engineering”Challenges in RegenerativeMedicine, 1(1):39-45.

  7. Sierad LN, Shaw EL, Launius R, McBride S, Storholt C, Poole R, Spence D, Miller K, Sosdian L, Allen K, Burton L, Iari A, Nagatomi J, Simionescu DT (2014) “Toward an Endothelial-Cell Covered Mechanical Valve; Surface Re-Engineering and Bioreactor Testing of Mechanical Heart Valves”Challenges in Regenerative Medicine, 1(1):22-34.

  8. Fercana G, Bowser D, Portilla MM, Langan EM, Carsten CG, Cull DL, Sierad LN, Simionescu DT (2014). “Platform technologies for decellularization, tunic-specific cell seeding and in vitro conditioning of extended length, small diameter vascular grafts”Tissue Eng Part C Methods,20(12):1016-27. PMCID: PMC4241864

  9. Throm Quinlan AM,Sierad LN, Capulli AK, Firstenberg LE, Billiar KL (2011). “Combining Dynamic Stretch and Tunable Stiffness to Probe Cell Mechanobiology In Vitro”PLoS One, 6(8):e23272. PMCID: PMC3156127

  10. Sierad LN, Simionescu A, Albers C,Chen J, Maivelett J, Tedder ME, Liao J, Simionescu DT (2010). “Design and Testing of a Pulsatile Conditioning System for Dynamic Endothelialization of Polyphenol-Stabilized Tissue Engineered Heart Valves”Cardiovasc Eng Technol, 1(2):138-153. PMCID: PMC3039844